Thursday, January 09, 2014

"Enterotypes" not so obvious after all?

An exciting possibility was that we could determine what "enterotype" (collection of bacterial species in the gut) was associated with obesity and, if causative, treat obesity by remodeling that enterotype to resemble one that promoted lean individuals. This article suggests that if enterotypes exist at all, we're going to have to look harder for them.

"We find that inter-study variability in the taxonomic composition of stool microbiomes far exceeds differences between lean and obese individuals within studies. Our analyses further reveal a high degree of variability in stool microbiome composition and diversity across individuals."

Gotta love open access.  Article via @iddux.

Thursday, January 02, 2014

Arguing against vaccines can cause deaths

Vaccines save lives. If you view yourself as a special case with unique sensitivities to vaccines, and are inspired toward activism against vaccines in general as a result, then you are morally obligated to ask whether such arguments are worth humans.

Given data showing that vaccines save lives, it follows that their negative effects are smaller than the diseases they prevent.*   Therefore advocating against vaccination - rather than advocating for different formulations while encouraging vaccination - is indistinguishable in effect from advocating that people die from preventable disease. That's a direct interpretation of what existing data mean.

* The conclusion is that successful anti-vaccination arguments lead to more deaths. If anyone has data showing that vaccine toxicity causes mortality at levels approaching the diseases they prevent, please share. I don't care about being wrong but really do care about accuracy. That said, note that the above reasoning doesn't change with power of anecdote. Some people have horrific reactions to vaccines. People also have horrific reactions to whooping cough, hepatitis, influenza and smallpox.